Learn more about iontophoresis as a treatment option for managing hyperhidrosis, including how it works, what to expect, and how to optimize chances of success.
Nov 14, 2024
Written by
Ashley C. Allen
Iontophoresis treatments have become a popular option for people dealing with hyperhidrosis, a medical condition that causes excessive sweating.
This treatment option uses a mild electric current to reduce sweat production, offering relief to those who might struggle with other methods.
Iontophoresis is a drug-free, non-invasive treatment that provides long-lasting relief with consistent use.
Iontophoresis is a simple, drug-free treatment option for those with hyperhidrosis (excessive sweating). This method uses a mild electric current that flows through water to reach the skin’s surface, reducing sweat production in targeted areas like the hands, feet, and underarms. The device itself is easy to use and compact, usually made up of a small unit with shallow trays that you fill with tap water for treatment sessions. It’s designed for convenience, making at-home treatments easy to fit into your routine.
For people with focal hyperhidrosis—meaning excessive sweating in specific areas rather than all over—iontophoresis can make a huge difference. It’s a non-invasive approach that skips harsh medications or complex procedures. This is particularly helpful for those dealing with specific subtypes of focal hyperhidrosis, such as sweaty palms (palmar hyperhidrosis), underarms (axillary hyperhidrosis), or both sweaty palms and soles (palmoplantar hyperhidrosis). By directly targeting the sweat glands in these areas, iontophoresis provides lasting relief from excessive sweating with a less demanding maintenance schedule after initial treatment is complete.
Iontophoresis is recommended when other treatments—like antiperspirants or medications—don’t provide enough relief. Healthcare providers suggest it because it’s non- invasive and generally has fewer side effects. People with palmoplantar hyperhidrosis find it especially useful since these areas are easy to treat with iontophoresis machines, which can be used at home for convenience.
One major benefit of iontophoresis is that it’s simple to do at home with a machine designed for personal use. This flexibility allows you to set a treatment schedule that fits your lifestyle. Unlike antiperspirants that need constant reapplication, iontophoresis works on a deeper level, so once results appear, it requires less frequent upkeep.
While iontophoresis is generally safe, it isn’t for everyone. People with pacemakers or metal implants, or those who are pregnant, should avoid it. Consulting a healthcare provider beforehand is essential, especially if you have any skin sensitivities or health concerns.
Iontophoresis uses a mild electrical current applied to the skin’s surface, on the outer layer, called the stratum corneum. The current helps manage sweat production by slowing down the activity of the sweat glands over time.
For most people, tap water alone is enough to conduct the current effectively because minerals in the water help it reach the sweat glands. Some people may add a medical agent to boost results, but often, plain tap water does the job well.
To get the best results, iontophoresis requires a consistent schedule. Most people start with three to four sessions per week, each lasting 20-30 minutes. As the patient begins to experience an improvement in symptoms, sessions can be reduced to a maintenance schedule, the most common cadence being once a week. This approach makes it easier to keep the sweat glands under control over time, providing ongoing relief with minimal interruption.
Getting familiar with the iontophoresis experience can make it easier to start your treatment. Here’s what you need to know to feel prepared and confident.
Getting ready for an iontophoresis session is simple. Before each session, make sure your skin is clean and check for any cuts or irritation. Treatment should be delayed if any cuts or irritation are present, or until you’ve spoken with your healthcare provider.
Some people find it helpful to apply a thin layer of petroleum jelly (like Vaseline) to sensitive spots. Petroleum jelly acts as a barrier, especially if you have drier skin, which reduces tingling or irritation from the electric current.
During a session, you’ll place your hands, feet, or another area like your underarms in shallow trays of tap water. The machine sends a small electric current through the water, creating a sensation that most describe as a gentle tingling or buzzing. It’s similar to the feeling when your foot falls asleep, but much softer and easy to get used to.
If the tingling feels too strong, you can always start with a lower current and gradually increase it as you adjust. The intensity can also vary based on skin sensitivity and water quality, so feel free to experiment with what’s comfortable for you.
Many people see a reduction in sweat after a week or two of regular treatments. Consistency is key — results will vary depending on how closely you follow your regimen. People often find that the sweat glands become less active over time, meaning longer breaks between treatments are possible.
Side effects are generally mild, with the most common being dryness, redness, or minor skin irritation. Using a moisturizer after each session can help keep your skin comfortable.
Serious adverse effects are rare, but if you notice significant discomfort or skin changes, it’s best to consult a healthcare provider.
Iontophoresis results depend on consistent treatment adherence as recommended by your healthcare provider as well as a few tricks to get the most out of each session. Here’s how you can maximize your results.
It may be tempting to skip sessions once you see results, but sticking to the recommended schedule helps maintain progress. Keeping up with maintenance sessions even after the initial success can help prevent the sweat from returning. This is where establishing a treatment schedule can be incredibly useful, especially for those with long-term hyperhidrosis concerns.
The quality of the water can impact iontophoresis results. Tap water usually works well, but in areas with very soft water (lacking certain minerals) results can be less effective. Adding a small amount of baking soda can improve conductivity, or in some cases, a healthcare provider may suggest adding a transdermal drug delivery agent to improve sweat reduction.
Some people add glycopyrrolate, an anticholinergic drug, to the water during iontophoresis. This option can enhance effectiveness, especially in stubborn cases, but it should be done under medical supervision to avoid possible side effects. Glycopyrrolate can enhance transdermal iontophoresis by increasing the treatment's potency in areas that are typically more resistant.
Iontophoresis has shown a high success rate, with many patients reporting a significant reduction in the amount of excess sweating they experience. For those dealing with palmoplantar hyperhidrosis (sweaty hands and feet), it’s especially promising; studies report that over 80% of users see an improvement. Staying consistent with the treatment and getting comfortable with your machine can make all the difference in reaching the best results. Think of it as a routine—like brushing your teeth. The more you stick with it, the more you’ll likely see the payoff.
Beyond reducing sweat, many people feel a weight lifted when they no longer have to worry about sweaty handshakes or damp clothes in social or work settings. Imagine the confidence boost when you don’t have to think twice about reaching out for a handshake or presenting in front of a crowd. This kind of relief can have a huge, positive impact on daily life, making it easier to focus on what really matters.
If you’re considering buying a machine, understanding what to look for can make a big difference. Here’s what you should know about purchasing one.
Prices can vary, with most at-home iontophoresis machines costing between $200 and $1,000, depending on features and quality. While it may seem expensive upfront, the ability to do treatments at home can save both time and long-term costs. Investing in a machine with adjustable current levels and durability will improve your treatment experience and provide reliable, long-lasting relief from hyperhidrosis.
In the U.S., iontophoresis machines for treating hyperhidrosis are regulated by the FDA, which classifies them as medical devices. This classification means the machines meet safety standards for home use. While most models require a prescription, not all do, so it’s a good idea to check with your healthcare provider or the machine manufacturer.
If iontophoresis sounds right for you, connect with a healthcare provider to find the best machine and get advice on making the most of this treatment.
For other personalized prescription solutions for managing hyperhidrosis, explore SweatRx – with tailored options and consistent care, you can take control of excessive sweating and find relief that fits your lifestyle.
Pariser DM, Ballard A. Iontophoresis for palmar and plantar hyperhidrosis. Dermatol Clin. 2014 Oct;32(4):491-4. doi: 10.1016/j.det.2014.06.009. Epub 2014 Jul 24. PMID: 25152342. https://www.sciencedirect.com/science/article/abs/pii/S073386351400076X?via%3Dihub
Formosa C, Thorne CS, Gatt A. Effectiveness of Iontophoresis in Treating Plantar Hyperhidrosis. J Am Podiatr Med Assoc. 2023 Jan-Feb;113(1):21-003. doi: 10.7547/21-003. PMID: 36905622. https://japmaonline.org/view/journals/apms/113/1/21-003.xml
Solish MJ, Savinova I, Weinberg MJ. A Practical Approach to the Diagnosis and Treatment of Palmar Hyperhidrosis. Plast Reconstr Surg Glob Open. 2022 Mar 7;10(3):e4172. doi: 10.1097/GOX.0000000000004172. PMID: 35265447; PMCID: PMC8901220. https://pmc.ncbi.nlm.nih.gov/articles/PMC8901220/pdf/gox-10-e4172.pdf
Chou P, Martin A, Ibraheim MK, Dao H Jr. Selecting an iontophoresis device: A source of consternation. J Am Acad Dermatol. 2024 Aug;91(2):364-366. doi: 10.1016/j.jaad.2024.04.029. Epub 2024 Apr 24. PMID: 38663747. https://www.jaad.org/article/S0190-9622(24)00644-3/fulltext
Stolman LP. Hyperhidrosis: medical and surgical treatment. Eplasty. 2008 Apr 18;8:e22. PMID: 18488053; PMCID: PMC2344132. https://pmc.ncbi.nlm.nih.gov/articles/PMC2344132/pdf/eplasty08e22.pdf
Dolianitis C, Scarff CE, Kelly J, Sinclair R. Iontophoresis with glycopyrrolate for the treatment of palmoplantar hyperhidrosis. Australas J Dermatol. 2004 Nov;45(4):208-12. doi: 10.1111/j.1440-0960.2004.00098.x. PMID: 15527429. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440- 0960.2004.00098.x?sid=nlm%3Apubmed
Chudry H. The treatment of palmar hyperhidrosis - a systematic review. Int J Dermatol. 2022 Nov;61(11):1303-1310. doi: 10.1111/ijd.15937. Epub 2021 Oct 15. PMID: 34653261. https://onlinelibrary.wiley.com/doi/10.1111/ijd.15937
